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These findings align with its known role as a repair-oriented signaling peptide

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In one of the most comprehensive approaches, a meta-analysis of 39 prospective cohort studies comprising over 15 million individuals suggested that an intake of up to 500 mg/d of total flavonoids was associated with a 27 %, 20 % and 23 % lower relative risk (RR) of cardiovascular disease (CVD), stroke and coronary heart disease (CHD), respectively (Reference Micek, Godos and Del Rio6)

264 Moreover, several studies have reported that GLP-1R agonists improve renal outcomes, especially in T2D patients who are at high risk of cardiovascular disease